Evidence map›Paper›PMID 41671335›Full record

ArticleJournal of the American Chemical Society2026

Overriding Stereochemical Outcomes in Cyclase Phase Total Synthesis: Enantioselective Synthesis of Habiterpenol and Dasyscyphin A.

Licheng Wu, Long H Nguyen, Liwen Yan, Haoyu Yin, Natsuki Mizuno, Alexander W Schuppe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A General Approach toJournal of the American Chemical Society · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Licheng WuDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Long H NguyenDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Liwen YanDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Haoyu YinDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Natsuki MizunoDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Alexander W SchuppeDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-6002-9110

Funding

Synthesis and Modification of Natural Products through Inert Bond Cleavage ReactionsR35GM156918 · NIGMS · VANDERBILT UNIVERSITY · PI Alexander W. Schuppe · 2025 to 2026
$792k
Acquisition of a 400 MHz NMR SpectrometerS10OD036222 · OD · VANDERBILT UNIVERSITY · PI SCHLEY, NATHAN DAVID · 2024 to 2024
$551k
NIGMS NIH HHS R35 GM156918NIH HHS S10 OD036222
6 · The paper itself

Abstract

Herein, we report the enantioselective total syntheses of habiterpenol and dasyscyphin A. By exploiting a quaternary carbon stereocenter epimerization protocol, we could override the intrinsic stereochemical bias of polyolefin cyclization reactions. Accordingly, we achieved the efficient and selective construction of the polycyclic scaffolds of both meroterpenoid natural products that bear an unconventional

Indexed as

TerpenesCyclizationStereoisomerismTerpenes

Identifiers

PMID41671335
PMCPMC12951448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.