ArticleBioconjugate chemistry2026
On-Resin DIAMSAR-Conjugated CD38-Targeted Peptides and Their Inverso and Dimeric-Inverso Analogs for PET Imaging of Multiple Myeloma.
Amit Kumar Sharma, Rui Tang, Alexander Zheleznyak, Brad Manion, Erin Teubner, Julie L Prior, Tommy Bauer, Michael Riley Dyer, Stephen Lees, Kimberly Kelly and 1 more
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In one paragraphArticle in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Amit Kumar SharmaMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Rui TangMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-2734-1003 Alexander ZheleznyakMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Brad ManionMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Erin TeubnerMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Julie L PriorMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Tommy BauerMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Michael Riley DyerMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0009-0006-4824-5076 Stephen LeesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, United States.
Kimberly KellyDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, United States.
Monica ShokeenMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0001-8114-9584 Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MExploring CD38 molecular biology and imaging in multiple myeloma pathogenesisR01CA248493 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2020 to 2024
$3.1MACQUISITION OF THE INVEON SMALL ANIMAL PET/CT SYSTEMS10RR025097 · NCRR · WASHINGTON UNIVERSITY · PI LAFOREST, RICHARD ANDRE · 2009 to 2009
$989kAcquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929kIVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599kMultispectral Optoacoustic Tomography (MSOT) SystemS10OD025264 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2018 to 2018
$544kNCI NIH HHS P30 CA091842NCI NIH HHS R01 CA248493NCRR NIH HHS S10 RR025097NIH HHS S10 OD025264NIH HHS S10 OD027042NIH HHS S10 OD030403
6 · The paper itselfAbstract
CD38 is an established biomarker of multiple myeloma (MM), and peptide-based radiopharmaceuticals targeted to this receptor offer a route to molecularly specific imaging. In this work, we identified a novel CD38-targeted peptide sequence (HAPWFRGGGGS) through phage display and synthesized it using automated solid-phase peptide synthesis. The peptide was modified by introducing a PEG
Indexed as
ADP-ribosyl Cyclase 1Membrane GlycoproteinsMultiple MyelomaPeptidesPositron-Emission TomographyRadiopharmaceuticalsAnimalsCell Line, TumorCopper RadioisotopesHumansMiceTissue DistributionADP-ribosyl Cyclase 1CD38 protein, humanCopper-64Copper RadioisotopesMembrane GlycoproteinsPeptidesRadiopharmaceuticals
Identifiers
PMID41671333
PMCPMC13003437
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