Evidence map›Paper›PMID 41671288›Full record

ArticlePloS one2026

The mechanism of aerobic exercise in ameliorating glycolipid metabolic disorders in metabolic syndrome rats via the miR-27a-PPARγ pathway.

Peiyun Wu, Zhizhuo Wang, Kunhui Li, Yao Gao, Jing Yang, Jinwu Wang, Chunlei Shan, Qi Guo, Han Yang, Juan Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peiyun WuDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Zhizhuo WangDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Kunhui LiDepartment of Rehabilitation, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yao GaoDepartment of Medical Laboratory, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China.
Jing YangDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Jinwu WangDepartment of Orthopedics, School of Medicine, Shanghai Key Laboratory of Orthopedic Implant, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Chunlei ShanDepartment of Rehabilitation, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qi GuoDepartment of Rehabilitation Sciences, School of Medicine and Health Sciences, Shanghai University, Shanghai, China.
Han YangDepartment of Medical Laboratory, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Juan WangDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Yuanshan JiangDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Cheng LinDepartment of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0009-0006-0409-8633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated how aerobic exercise improves metabolic disorders in rats with metabolic syndrome (MS) and explored the role of miR-27a in this process. MS was induced by a high-fat and high-sugar diet. After eight weeks of treadmill training, aerobic exercise was found to reduce metabolic abnormalities and decrease elevated miR-27a levels, while increasing the expression of PPARγ and key downstream molecules involved in glycolipid metabolism. Downregulating miR-27a via a viral vector produced benefits similar to those of exercise, and combining miR-27a inhibition with exercise led to further improvement. These results suggested that aerobic exercise alleviates MS-related metabolic disorders partly through suppressing miR-27a and promoting PPARγ signaling, revealing a potential therapeutic target.

Indexed as

GlycolipidsMetabolic SyndromeMicroRNAsPhysical Conditioning, AnimalPPAR gammaSignal TransductionAnimalsMaleRatsRats, Sprague-DawleyGlycolipidsMicroRNAsMIRN27 microRNA, ratPPAR gamma

Identifiers

PMID41671288
PMCPMC12893564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.