ArticlePloS one2026
Prevalence of polypharmacy and drug interactions in geriatric patients: A cross-sectional study from India.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Potential Drug-Drug Interactions in Patients Undergoing Hemodialysis:Saudi medical journal · 2026Observational
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10 authors.
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Abstract
backgroundPolypharmacy and potential drug-drug interactions (pDDIs) are major challenges in the management of elderly patients with multiple comorbidities, often leading to adverse drug events and increased healthcare burden.
aimThis study aimed to determine the prevalence and patterns of polypharmacy and pDDIs among elderly patients attending Yenepoya Medical College and Hospital, Mangalore, India.
methodsA cross-sectional study was conducted from January to June 2023 among 310 elderly patients (aged ≥60 years) selected through simple random sampling from both in-patient and out-patient departments. Polypharmacy was defined as the concurrent use of ≥5 medications, and excessive polypharmacy as ≥9 medications. Drug interaction screening was performed using UpToDate and Medscape interaction checker tools. Statistical analyses included descriptive statistics, t-tests, chi-square tests, and regression analysis, with significance set at p < 0.05.
resultsThe prevalence of polypharmacy was slightly higher in females (53.84%) than males (51.94%), with the highest rates observed in the 70-79 age group (48.88%). Most patients experienced moderate (50%) drug interactions. A significant gender difference was observed in the number of drugs prescribed at treatment (p = 0.0032), but not at discharge. Regression analysis identified gender (p = 0.018) and inpatient status (p < 0.001) as significant predictors of polypharmacy, while age was not (p = 0.719).
conclusionThis study reveals a high prevalence of polypharmacy among elderly patients attending Yenepoya Medical College and Hospital. Polypharmacy was found to be more prevalent among female patients, older age groups, and in inpatient wards. The distribution of drug interactions revealed a pervasive nature across various degrees, with moderate interactions being the most common. Future research should use larger samples, and diverse populations to better understand polypharmacy, drug interactions, and outcomes.
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