ArticlePloS one2026
Proteomic profiling of a Sporobolomyces yeast reveals global responses to UV-B-induced oxidative stress.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RESEARCH
backgroundUltraviolet-B (UV-B) radiation induces oxidative stress through the generation of reactive oxygen species, affecting organisms across all domains of life. While UV-stress responses have been extensively studied in the ascomycete yeast Saccharomyces cerevisiae and animal systems, little is known about the molecular mechanisms underlying UV tolerance in basidiomycete, UV-resistant yeasts. Carotenoid-producing yeasts of the genus Sporobolomyces represent an attractive model to investigate whether conserved oxidative stress pathways, including bZip transcription factor signalling analogous to the vertebrate Nrf2 pathway, contribute to UV tolerance. EXPERIMENTAL APPROACH: The UV-tolerant yeast Sporobolomyces sp. LEV-2 was exposed to UV-B irradiation for up to 24 hours. Quantitative multidimensional protein identification technology (MudPIT) mass spectrometry using tandem mass tag (TMT) labelling was applied to identify and quantify protein expression changes over time. Identified proteins were functionally annotated using InterProScan, KEGG tools and literature-based curation, and proteomic data were integrated with measurements of antioxidant activity and cell viability. RESULTS AND
conclusionsA total of 751 proteins were identified, including 105 stress-response proteins. UV-B exposure induced a coordinated oxidative stress response involving conserved signalling pathways (bZip, MAPK, FoxO, Ras and calcium signalling), antioxidant enzymes, heat-shock proteins and DNA repair factors. A bZip protein (LEV-2_XP_007274754.1) displayed Nrf2/Yap1-like behaviour, suggesting a central regulatory role in UV-induced stress signalling. A four-step model of UV adaptation was proposed, encompassing signalling, metabolic stress, antioxidant-driven adaptation and establishment of a stress-resistant state. These responses closely parallel UV- and oxidant-induced stress responses described in other fungi and in animal cells. NOVELTY AND SCIENTIFIC CONTRIBUTION: This study provides the first proteome-level analysis of UV-B stress adaptation in a Sporobolomyces yeast and demonstrate that UV tolerance relies on ancient, evolutionarily conserved oxidative stress mechanisms shared across eukaryotes, rather than yeast-specific pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.