ArticleNeonatology2026
Red Blood Cell Transfusion and Risk of Iron Overload in Preterm Infants: A Prospective Study on Serum Ferritin and Hepcidin.
Article in Neonatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
<p>Introduction: The aims of this study were to evaluate iron metabolism changes and overload risk in preterm infants after red blood cell transfusion (RBCT) and to assess hepcidin's diagnostic value.
methodsThis prospective study analyzed 72 preterm infants (mean GA: 30.1 weeks; BW: 1,356 g) at Shenzhen Children's Hospital (2023). Groups were stratified by the volume of RBCT (>40 mL/kg vs. ≤40 mL/kg). Serum ferritin (SF) and hepcidin levels were measured alongside clinical parameters.
resultsThe >40 mL/kg RBCT group had significantly lower GA (p = 0.039) and BW (p = 0.013). SF and hepcidin levels were elevated in the >40 mL/kg RBCT group (p < 0.001), with higher risks of iron overload (RR = 1.6, 95% CI: 1.3-2.3) and severe overload (RR = 4.5, 95% CI: 1.8-12.4). The volume of RBCT was an independent risk factor (p = 0.034). Hepcidin showed predictive value (area under the curve = 0.731, sensitivity: 92%, cutoff: 45.08 ng/mL).
conclusionsHigh-volume of RBCT (>40 mL/kg) significantly increase iron overload risk in preterm infants. Hepcidin demonstrates potential as a predictive biomarker. </p>.
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