Evidence map›Paper›PMID 41671186›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Optogenetic control of transition to metamorphosis.

Changyuan Wang, Denis F Faerberg, Yuka Sekine, Takeaki Ozawa, John J Tyson, Robert A Marmion, Stanislav Y Shvartsman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changyuan Wang *Department of Physics, Princeton University, Princeton, NJ 08544.ORCID 0009-0007-5432-9601
Denis F Faerberg *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.ORCID 0000-0003-2047-429X
Yuka SekineDepartment of Chemistry, School of Science, University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0003-0982-6848
Takeaki OzawaDepartment of Chemistry, School of Science, University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-3198-4853
John J TysonDepartment of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.ORCID 0000-0001-7560-6013
Robert A MarmionLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-3895-0584
Stanislav Y ShvartsmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-9152-9334

Funding

Quantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01HD085870 · NICHD · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2016 to 2020
$1.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01GM141843 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2021 to 2024
$1.2M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD085870HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM134204HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM141843NHGRI NIH HHS T32 HG003284NICHD NIH HHS R01 HD085870NIGMS NIH HHS R01 GM134204NIGMS NIH HHS R01 GM141843
6 · The paper itself

Abstract

System identification approaches are commonly used in engineering to infer simple yet predictive models of complex systems from their responses to time-dependent perturbations. Here, we apply this strategy at the whole organism scale, establishing a predictive model of commitment to metamorphosis in

Indexed as

Drosophila melanogasterMetamorphosis, BiologicalOptogeneticsAnimalsDrosophilaDrosophila ProteinsLarvaModels, BiologicalSignal TransductionDrosophila Proteinsecdysonejuvenile-to-adult transitionmodelingoptogenetics

Identifiers

PMID41671186
PMCPMC12912986

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.