Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Kotaro ShimoyamaDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Mamoru TanidaDepartment of Physiology II, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Jun ArugaDepartment of Medical Pharmacology, Nagasaki University Institute of Biomedical Sciences, Nagasaki 852-8523, Japan.
Tomohiro FurusatoGraduate School of Integrated Science and Technology, Nagasaki University, Nagasaki 852-8521, Japan.ORCID 0000-0003-4899-0966
Chia-Hsien WuDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-2487-2984
Yasuna NakamuraDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0003-3029-2852
Daisuke TakahashiDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Go KanzakiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0002-7795-369X
Atsuhiro MaedaDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Takao ShioyaDepartment of Physiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
Nobuo TsuboiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Chikara AbeDepartment of Physiology, University of Fukui School of Medical Sciences, Fukui 910-1193, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0003-1838-7998
Ryusuke UmeneDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0009-0001-7452-235X
Tsuyoshi InoueDepartment of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0003-2208-7584
Funding
Japan Agency for Medical Research and Development (AMED) JP22gm6210013MEXT | Japan Science and Technology Agency (JST) JPMJFR210JMEXT | Japan Society for the Promotion of Science (JSPS) 22H03090SRF 2023G007Terumo life science foundation 2022vyPS
6 · The paper itself
Abstract
Abdominal ultrasound has emerged as a noninvasive modality with immunomodulatory potential. Although its anti-inflammatory effects have been demonstrated in various disease models, the underlying mechanisms remain unclear. Previous studies suggest that ultrasound promotes anti-inflammatory macrophage polarization via α7 nicotinic acetylcholine receptor (α7nAChR) signaling in the spleen. However, the upstream events initiating this response have not been elucidated. Here, we demonstrate that abdominal ultrasound activates afferent vagal fibers and suppress systemic inflammation. In a murine model of lipopolysaccharide (LPS)-induced endotoxemia, abdominal ultrasound significantly reduced plasma TNF-α levels. This anti-inflammatory effect was attenuated by subdiaphragmatic vagotomy (SDVx) or afferent vagal blockade. Electrophysiological recordings revealed increased cervical vagus nerve activity during ultrasound stimulation, which was eliminated by intraperitoneal lidocaine, confirming activation of abdominal sensory afferents. Furthermore, abdominal ultrasound induced c-Fos expression in the nucleus tractus solitarius (NTS), consistent with central activation via vagal afferent input. These findings provide direct mechanistic evidence that abdominal ultrasound stimulates afferent vagal pathways.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects. · full record | OpenQuestion