Evidence map›Paper›PMID 41671179›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Synaptic transmission: Munc13 assembles onto PI(4,5)P

Feng Li, Abhijith Radhakrishnan, Sudhanshu Gautam, Gabriel Diaz, Ramalingam Venkat Kalyana Sundaram, Jeff Coleman, Hong Zheng, Kirill Grushin, Matthieu Chavent, James E Rothman and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feng LiDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0003-1799-9570
Abhijith RadhakrishnanDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0001-8107-3487
Sudhanshu GautamDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0009-0008-0892-2284
Gabriel DiazLaboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, Université de Toulouse, CNRS, Université Paul Sabatier, Toulouse F-31400, France.ORCID 0000-0002-6724-0397
Ramalingam Venkat Kalyana SundaramDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0002-0232-4186
Jeff ColemanDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0003-0110-9289
Hong ZhengDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.
Kirill GrushinDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.
Matthieu ChaventLaboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, Université de Toulouse, CNRS, Université Paul Sabatier, Toulouse F-31400, France.ORCID 0000-0003-4524-4773
James E RothmanDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0003-4822-4161
Frederic PincetDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0002-4243-2157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Munc13-1 is a key protein involved in priming synaptic vesicles for rapid release at the presynaptic plasma membrane. It was previously revealed that Munc13-1 cycles between at least two alternate conformations, an upright (open) molecular conformation organized as a trimer and a lateral (closed) conformation organized as a hexagon. Munc13 binds PI(4,5)P

Indexed as

Nerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateSynaptic TransmissionSynaptic VesiclesAnimalsCryoelectron MicroscopyProtein BindingProtein DomainsProtein MultimerizationRatsSyntaxin 1Nerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateSyntaxin 1Unc13a protein, ratC2 domainscryoelectron tomographydiacylglycerolSyntaxin-1ATIRF

Identifiers

PMID41671179
PMCPMC12912961

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.