ArticleTrends in hearing
Benefits of Enhanced Phase-Locking for Binaural Coding of Amplitude-Modulated Sounds.
Article in Trends in hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural processing of interaural time and level differences (ITDs/ILDs) underlies binaural sound localization. Neurons of the mammalian lateral superior olive (LSO) are sensitive to ILDs and envelope-ITDs of acoustic stimuli. Bushy cells in the anteroventral cochlear nucleus convey relevant information from auditory nerve (AN) fibers to the LSO. More specifically, spherical bushy cells (SBCs) send ipsilateral excitatory inputs, while globular bushy cells (GBCs) project to the contralateral medial nucleus of the trapezoid body that provides inhibitory inputs to the LSO. Previous studies in vivo reported an enhancement of phase-locking in bushy cells compared to AN. This enhancement has been hypothesized to benefit temporal coding in binaural neurons, but its actual contribution in LSO remains unclear. Here we investigate this question by computational modeling of binaural circuity incorporating the AN, SBC/GBC, and LSO stages. Both bushy cell models were calibrated to replicate known physiological responses, including the representative peristimulus time histograms for high-frequency tones and enhanced phase-locking to low-frequency envelopes. We then simulated the binaural tuning of LSO with and without the bushy cell stage. The synaptic inputs to the LSO model were adjusted so that the simulated ILD-tuning remains unaltered between the input configurations. By adding the bushy cell stage, the simulated binaural response of LSO became more sharply tuned for envelope-ITDs. Furthermore, the envelope-ITD sensitivity was extended up to around 600 Hz, matching previously observed physiological limits. These results provide computational evidence for the functional benefit of having bushy cells in the binaural sound localization circuit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.