Evidence map›Paper›PMID 41671061›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo.

Joshua N Curry, Xiao-Tong Su, Qi Wu, Yujiro Maeoka, Chao-Ling Yang, Eric Delpire, Robert A Fenton, Paul A Welling, David H Ellison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joshua N CurryDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-7364-964X
Xiao-Tong SuDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0001-8121-8105
Qi WuDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-6249-4091
Yujiro MaeokaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.ORCID 0000-0003-1808-2772
Chao-Ling YangDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0002-3702-1599
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-1623-199X
Paul A WellingDepartment of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-0719-8705
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0003-2915-265X

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
Training in Translational Science and Cardiovascular MedicineT32HL094294 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2009 to 2018
$3.5M
Role of Kir4.1 in regulating NCC and ROMK in DCTR01DK133220 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID HOADLEY, WANG, WENHUI · 2022 to 2025
$2.6M
Training in Translational Science and Cardiovascular ResearchT32HL166128 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Nabil J Alkayed · 2023 to 2026
$2.0M
Danish Research Agency Infrastructure Program 5229-0009BFondation Leducq (Leducq Foundation) 17CVD05HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL094294HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK093501HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK133220NHLBI NIH HHS T32 HL094294NHLBI NIH HHS T32 HL166128NIDDK NIH HHS L70 DK140988NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK133220
6 · The paper itself

Abstract

The epithelial sodium channel (ENaC) is essential for sodium reabsorption and potassium homeostasis in the distal nephron, where its activity is controlled by mineralocorticoid signaling and downstream proteolytic processing of channel subunits. Although cleavage of the γ-ENaC subunit has been implicated in aldosterone-mediated sodium transport, the identity of mineralocorticoid receptor (MR)-regulated proteases responsible for this process remains uncertain. Here, we investigated the role of kallikrein-1 (encoded by

Indexed as

Epithelial Sodium ChannelsKidneyKidney Tubules, CollectingTissue KallikreinsAldosteroneAnimalsKallikreinsMaleMiceMice, Inbred C57BLMice, KnockoutProteolysisSodiumAldosteroneEpithelial Sodium ChannelsKallikreinsScnn1g protein, mouseSodiumTissue Kallikreinsaldosteroneepithelial sodium channelkallikreinpotassium

Identifiers

PMID41671061
PMCPMC13001718

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.