ArticleShock (Augusta, Ga.)2026
Effects of Dobutamine and Vasopressin on Microcirculation and Mitochondrial Function in the Liver and Colon of Septic Rats: A Randomized Placebo-Controlled Trial.
Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Monitoring and Targeted Regulation of Oxygen Metabolism in Pediatric Sepsis: Current Paradigms and Future Perspectives.International journal of molecular sciences · 2026Review
- Milrinone and levosimendan improve microvascular perfusion in septic rats: a randomized, placebo-controlled trial.Intensive care medicine experimental · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is characterized by systemic inflammation and microcirculatory dysfunction, contributing to multiorgan failure. In the gastrointestinal tract, impaired microcirculation and mitochondrial dysfunction promote barrier failure and bacterial translocation. While dobutamine is commonly used to augment cardiac output in septic shock, its direct effects on intestinal microcirculation and mitochondrial respiration remain unclear. The microcirculatory impact of adjunctive low-dose vasopressin is similarly uncertain.
methodsTwenty-four hours after colon ascendens stent peritonitis or sham surgery, 88 male Wistar rats were randomized to receive vehicle, vasopressin, dobutamine, or their combination under septic or sham conditions. Colonic and hepatic microcirculatory oxygenation (µHbO 2 ) and microvascular blood flow (µFlow) were measured for 90 minutes using tissue-reflectance spectrophotometry and laser Doppler flowmetry. Mitochondrial respiration was assessed in colon and liver homogenates of septic animals by high-resolution respirometry. Microcirculatory data were analyzed using mixed-effects models with Tukey's and Dunnett's post hoc tests. Mitochondrial data were analyzed using the Kruskal-Wallis test. A two-sided P < 0.05 was considered statistically significant.
resultsIn septic rats, dobutamine significantly improved colonic microvascular oxygenation (∆µHbO 2 10.2% ± 13.4% vs. -2.3% ± 4.4% in controls and vs. baseline, P < 0.05) and microvascular blood flow (∆µFlow 30 ± 20 arbitrary units vs. baseline, P < 0.05). Combined dobutamine and vasopressin increased microvascular blood flow (∆µFlow 28 ± 27 arbitrary units vs. baseline, P < 0.05) but did not improve tissue oxygenation. Hepatic microcirculation and mitochondrial respiration remained largely unaltered.
conclusionsDobutamine improves colonic microcirculation in sepsis, whereas concomitant vasopressin attenuates its oxygenation effects.
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