Evidence map›Paper›PMID 41670833›Full record

ArticleMolecular neurobiology2026

Conditional Deletion of Isl1 Disrupts Cochlear Sensory and Neuronal Development, Leading to Hearing Loss.

Lenka Gmiterkova, Mitra Tavakoli, Kateryna Pysanenko, Romana Bohuslavova, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lenka Gmiterkova *Institute of Biotechnology CAS, Prumyslova 595, 25250, Vestec, Czechia.
Mitra Tavakoli *Institute of Biotechnology CAS, Prumyslova 595, 25250, Vestec, Czechia.
Kateryna PysanenkoInstitute of Experimental Medicine CAS, Videnska 1083, 142 20, Prague, Czechia.
Romana BohuslavovaInstitute of Biotechnology CAS, Prumyslova 595, 25250, Vestec, Czechia.
Josef SykaInstitute of Experimental Medicine CAS, Videnska 1083, 142 20, Prague, Czechia.
Bernd FritzschDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA. bfritzsch@unmc.edu.ORCID http://orcid.org/0000-0002-4882-8398
Gabriela PavlinkovaInstitute of Biotechnology CAS, Prumyslova 595, 25250, Vestec, Czechia. gpavlinkova@ibt.cas.cz.ORCID http://orcid.org/0000-0002-5689-6577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms guiding cochlear development remain incompletely understood. Here, we used conditional deletion mouse models (both sexes) to define the spatiotemporal roles of the transcription factors NEUROD1 and ISL1 during cochlear neurosensory development. Delayed deletion of Neurod1 using Atoh1

Indexed as

CochleaGene DeletionHearing LossLIM-Homeodomain ProteinsNeurogenesisNeuronsTranscription FactorsAnimalsBasic Helix-Loop-Helix ProteinsEvoked Potentials, Auditory, Brain StemFemaleMaleMiceSpiral GanglionBasic Helix-Loop-Helix Proteinsinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsTranscription FactorsCochleaHearing functionNeurogenesisSensory hair cellsTranscription regulation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.