Evidence map›Paper›PMID 41670812›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Influence of subgroup, location, and tumor volume in medulloblastoma surgery and consideration for second look surgery: a single institution experience.

Erica A Power, Andrew D Pumford, Lionel Futso-Kamga, Victora M Silvera, Julian S Rechberger, Leda Wang, Jonathon D Schwartz, David J Daniels

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Erica A PowerLoyola Stritch School of Medicine, Maywood, IL, 60141, USA.
Andrew D PumfordMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Lionel Futso-KamgaMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Victora M SilveraDepartment of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Julian S RechbergerDepartment of Neurosurgery, Rochester, MN, USA.
Leda WangMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Jonathon D SchwartzDepartment of Pediatrics, Rochester, MN, USA.
David J DanielsDepartment of Neurosurgery, Rochester, MN, USA. Daniels.David@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe goal of this study was to systematically analyze tumor subgroup, location, and volume in relationship to extent of resection (EOR) through a retrospective approach and examine the role for second-look surgery with a single-institution case series.

methodsRetrospective data review of pathologically confirmed medulloblastoma patients under the age of 21 who underwent surgery at the Mayo Clinic Rochester.

resultsThere were 45 patients who met the inclusion criteria. All subgroups were represented, and those without subgroup data were classified as unknown with histopathologic confirmed grade IV medulloblastoma. The most common location of tumors was the fourth ventricle, though this varied by subgroup. The foramen of Lushka was the most invaded structure. Tumor size and volume were classified with respect to EOR and subgroup and there was no statistically signifcant difference noted. There were 5 non-WNT non-SHH subgroup patients who underwent second look surgery. EOR and the location of residual tumor varied, but GTR was achieved in all cases.

conclusionsWhen indicated, second look surgery is safe and offers an opportunity to achieve GTR. The EOR and role of second look surgery remain controversial, and larger multicenter studies will be needed.

Indexed as

Cerebellar NeoplasmsMedulloblastomaNeurosurgical ProceduresSecond-Look SurgeryAdolescentChildChild, PreschoolFemaleFourth VentricleHumansInfantMagnetic Resonance ImagingMaleNeoplasm GradingNeoplasm InvasivenessNeoplasm, ResidualExtent of resectionMedulloblastomaSecond-look surgery

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PMID41670812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.