Evidence map›Paper›PMID 41670787›Full record

ReviewBiochemical genetics2026

The Impact of NEAT1 on Inflammatory Responses and Processes in Arthropathic Diseases: Latest Findings and Perspectives.

Suleiman Ibrahim Mohammad, Raed Obaid Saleh, Hamza Abu Owida, Zahraa Abbas Al-Khafaji, Pooja Varma, Asokan Vasudevan, Wesam R Kadhum, Ahmed Read Al-Tameemi, Yasser Fakri Mustafa, Shakeel Ahmed Ansari

Abstract readReview
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In one paragraph

Review in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Suleiman Ibrahim MohammadElectronic Marketing and Social Media, Economic and Administrative Sciences, Zarqa University, Zarqa, Jordan. dr_sliman@yahoo.com.
Raed Obaid SalehDepartment of Medical Laboratories Techniques, College of Health and Medical Techniques, University of Al Maarif, Al Anbar, 31001, Iraq. Dr.raed.obaid@uoa.edu.iq.
Hamza Abu OwidaMedical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Zahraa Abbas Al-KhafajiCollege of Pharmacy, The Islamic University, Najaf, Iraq.
Pooja VarmaDepartment of Psychology, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Asokan VasudevanFaculty of Business and Communications, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia.
Wesam R KadhumDepartment of Pharmaceutics, College of Pharmacy, University of Kut, Wasit, 52001, Iraq.
Ahmed Read Al-TameemiDepartment of Biomedical Engineering, AL-Nisour University College, Baghdad, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Shakeel Ahmed AnsariDepartment of Biochemistry, General Medicine Practice Program, Jeddah 21442, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arthropathies are joint-related disorders with diverse etiologies but standard clinical and radiographic features. There is growing evidence that long non-coding RNAs (lncRNAs) play a crucial role in regulating the development and progression of certain diseases. Nuclear-enriched abundant transcript 1 (NEAT1) is one of these lncRNAs. It is common and helps control transcription and epigenetics, especially during inflammation. This narrative review presents current data on NEAT1's role in inflammation and its contribution to the development of arthropathies, including psoriasis, rheumatoid arthritis, osteoarthritis, SLE, Behçet's disease, and hemophilic arthropathy. The research demonstrated that NEAT1 regulates immune cell activity, inflammasome formation, and inflammatory signaling pathways through interactions with miRNAs and transcriptional regulators. The activity, progression, and response to treatment of the disease are all linked to its dysregulated expression. In conclusion, NEAT1 appears to be a significant regulator of inflammation and joint disease, potentially serving as both a therapeutic target and a biomarker for joint-related disorders. More mechanistic and translational studies are needed to better understand how it works and how it might be used in medicine.

Indexed as

InflammationJoint DiseasesRNA, Long NoncodingAnimalsGene Expression RegulationHumansMicroRNAsMicroRNAsNEAT1 long non-coding RNA, humanRNA, Long NoncodingArthritic diseasesInflammationLncRNANEAT1

Identifiers

PMID41670787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.