Evidence map›Paper›PMID 41670764›Full record

ArticleActa parasitologica2026

Hematological and Biochemical Outcomes of Leishmania Infantum Infection in the South American Coati (Nasua nasua) in an Endemic Area of Visceral Leishmaniasis in Central Western Brazil.

Gabriel Carvalho de Macedo, André Luiz Rodrigues Roque, Filipe Martins Santos, Wanessa Teixeira Gomes Barreto, Carina Elisei de Oliveira, William Oliveira de Assis, Grasiela Edith de Oliveira, Andreza Castro Rucco, Gisele Braziliano de Andrade, Alanderson Rodrigues da Silva and 5 more

Abstract read
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In one paragraph

Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gabriel Carvalho de MacedoLaboratory of Trypanosomatid Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil. carvalhodemacedo@gmail.com.ORCID http://orcid.org/0000-0002-4596-5733
André Luiz Rodrigues RoqueLaboratory of Trypanosomatid Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-8740-052X
Filipe Martins SantosDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0003-2032-8129
Wanessa Teixeira Gomes BarretoLaboratory of Spatial Ecology and Conservation, São Paulo State University, Rio Claro, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2970-1321
Carina Elisei de OliveiraDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0001-9240-4376
William Oliveira de AssisDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0003-3327-0800
Grasiela Edith de OliveiraDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0003-0837-7489
Andreza Castro RuccoDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0001-5470-3527
Gisele Braziliano de AndradeDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0001-6289-9945
Alanderson Rodrigues da SilvaDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0001-5560-1098
Nayara Yoshie SanoDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0003-2771-5471
Julia Gindri Bragato PistoriDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0001-9352-1048
Samanta Cristina das Chagas XavierLaboratory of Trypanosomatid Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-3475-0075
Ana Maria JansenLaboratory of Trypanosomatid Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-5804-6210
Heitor Miraglia HerreraDepartment of Environmental Sciences and Agricultural Sustainability, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil.ORCID http://orcid.org/0000-0003-2404-8765

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309507/2023-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 311769/2023-3Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro SEI E-26/200.295/2025
6 · The paper itself

Abstract

purposeWildlife is a major source of infectious diseases affecting humans and domestic animals; however, the impacts of parasitism on naturally parasitized fauna remain largely unknown. In this study, we evaluated the outcomes of Leishmania infantum infection in blood parameters of South American coatis (Nasua nasua) in an area endemic for leishmaniasis in the Brazilian Midwest region.

methodsIn total, 128 blood samples were obtained from 77 adult South American coatis. Health status was inferred from hematological and biochemical parameters categorized into the following indicators: red blood cell count, coagulation, immune response (IMRI), infection response, kidney damage, liver damage (LDI), cardiac damage, skeletal muscle damage (SMDI), nutritional profile (NPI), and protein profile (PPI). We compared the hematological and biochemical parameters of seropositive, DNA detection and negative groups using ANOVA and Kruskal-Wallis tests, and assessed the direct effects of L. infantum on health indicators and body condition (BC) through path analysis.

resultsOur findings showed that L. infantum infection affected LDI, IMRI, PPI and NPI but had no negative impact on BC. However, BC was influenced by SMDI, IMRI, NPI and KDI regardless of parasitism.

conclusionsOur results indicate that L. infantum may cause long-lasting subclinical infections associated with alterations in liver function, immune response, and protein and nutritional profiles of coatis living in urban areas of the Brazilian Midwest. We highlight the importance of monitoring the impact of L. infantum infections on wild mammals in leishmaniasis-endemic areas.

Indexed as

Leishmania infantumLeishmaniasis, VisceralProcyonidaeAnimalsAnimals, WildBrazilEndemic DiseasesFemaleMaleConservation biologyHealthProcyonidaeUrban ecology

Identifiers

PMID41670764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.