SynthesisJournal of neurology2026
Disrupted and reorganized connectivity of brain networks in multiple sclerosis: a systematic review and meta-analysis of resting-state functional MRI.
Synthesis in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Graded hypergravity is associated with large-scale reorganization of resting-state cortical networks: EEG evidence from a neurological inactivity phenotype.IBRO neuroscience reports · 2026Article
- PET-MRI effects of N-acetylcysteine in patients with multiple sclerosis.IBRO neuroscience reports · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundAbnormalities in large-scale brain functional networks are implicated in multiple sclerosis (MS) and linked to clinical impairments, but reported findings remain heterogeneous due to methodological and sample variations.
methodsBased on 25 resting-state functional magnetic resonance (rsfMRI) imaging studies (1,524 MS patients and 886 healthy controls (HCs)), in which the independent component analysis (ICA) method was used to evaluate the resting-state functional connectivity (rsFC) changes in default mode (DMN), sensorimotor (SMN), salience (SN), and visual (VN) networks, a meta-analysis was performed using the anisotropic effect size seed mapping (AES-SDM) software to quantify the differences between MS patients and HCs. The heterogeneity was assessed, and a meta-regression analysis was conducted on age, disease duration, Expanded Disability Status Scale scores, and T2-hyperintense lesion volume.
resultsCompared with HCs, MS exhibited increased rsFC in left anterior cingulate/paracingulate gyri and right superior frontal gyrus (DMN), bilateral precentral gyrus and right postcentral gyrus (SMN), right angular gyrus (SN), whereas hypoconnectivity was observed in left posterior cingulate gyrus (DMN), right supplementary motor region and left precentral gyrus (SMN), right insula (SN), and left superior parietal gyrus (VN). The Meta-regression analysis revealed no significant correlation between these altered rsFC and clinical variables. DATA
conclusionsThis study demonstrates widespread and complex rsFC abnormalities in several neural networks in MS, particularly within core regions of the DMN, SMN, VN, and SN. Together with a descriptive synthesis of additional RSNs, these rsFC disruptions and reorganizations may represent intrinsic neuropathological alterations in MS, which further elucidate the pathophysiological mechanisms of functional abnormalities in MS at a large-scale level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.