ArticleThe Journal of organic chemistry2026
Schmidt Reaction of Hydroxyalkyl Azides with Acyclic Ketones.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
The Schmidt reaction of hydroxyalkyl azides with acyclic ketones has been investigated. Specifically, we show that this reaction consistently generates an ester product via hydrolysis of an intermediate iminium ether. This is in contrast to most cyclic ketones, which provide lactams. Moreover, the addition of nucleophiles to the intermediate affords amide products through a mechanistically distinct pathway. Studies related to the reaction scope, regioselectivity, and mechanism are also reported.
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Registered trials
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