ArticleInvestigative ophthalmology & visual science2026
Applied Anatomical and Morphological Characterization of the Ocular Surface of the African Spiny Mice: Acomys cahirinus.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The Acomys cahirinus (A. cahirinus) are a valuable animal model for studying adaptations to dry harsh climates. Recently, Acomys have emerged as a powerful model for studying tissue regeneration: regenerating large sections of skin tissue without scarring. This study characterizes the anatomy and morphology of the ocular surface and accessory glands of the A. cahirinus. Methods: The ocular surface was assessed, and cornea and accessory glands collected for A.cahirinus at 3 months, and CD-1 mice at 8 weeks. The corneas were imaged by optical coherence tomography (OCT), in vivo confocal microscopy (HRTIII), and under a stereomicroscope with white light and a ring light. Tissues were collected and processed for histological analysis, and stained with hematoxylin and eosin (H&E), periodic acid-Shiff staining (PAS), and alcian blue, and processed for immunostaining. Results: A. cahirinus present pockets of cells within the corneal epithelium with features of epithelial progenitor cells, and fibrovascular ridges within the limbal region that contain limbal epithelial stem cells. A. cahirinus present few Meibomian glands (MGs) within the lower lid, however, they present large MGs that extend laterally and posteriorly from the temporal eyelid margin. Clusters of serous glands are present at the most distal region of these MGs. Lacrimal glands were identified with serous secretion, and harderian glands were identified with apocrine secretion. Conclusions: The A. cahirinus present key adaptations that enable them to maintain a healthy ocular surface despite living in a semi-arid climate and are a powerful model for identifying mechanisms to prevent dry eye disease and to promote scarless regeneration in mammals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.