Evidence map›Paper›PMID 41670372›Full record

ArticleJournal of virology2026

DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates

Siyu Lin, Xiaotong Chen, Meihua Luo, Xiaolu Cui, You Dai, Zhen Sun, Guikang Wang, Hong Peng, Ping Ling, Jinlin Long and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siyu Lin *Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Xiaotong Chen *Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Meihua LuoGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Xiaolu CuiGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
You DaiGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Zhen SunSchool of Basic Medical Sciences, Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou, Guangdong, China.
Guikang WangGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Hong PengEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Ping LingPICU, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou, China.
Jinlin LongEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Huifang ZhouEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Changlei LuoEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Yan-Fei QiDepartment of Pharmacology, College of Osteopathic Medicine, Duquesne University, Pittsburgh, Pennsylvania, USA.
Ke ZhangGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.ORCID 0000-0001-6777-6290
Yu-Si LuoGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Institute of Virology, The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.ORCID 0000-0002-6497-4942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human respiratory syncytial virus (RSV) is a major pathogen causing acute lower respiratory tract infections in infants, young children, and elderly people worldwide. Viruses often hijack host cell ion channels to optimize their intracellular environment, positioning ion channel blockers as promising antiviral agents. On the outer mitochondrial membrane, voltage-dependent anion channel protein 1 (VDAC1) plays a crucial role in regulating mitochondrial pathway apoptosis and maintaining cellular homeostasis. This study systematically evaluates the antiviral activity of the VDAC1 inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), both

Indexed as

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAntiviral AgentsApoptosisRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsVoltage-Dependent Anion Channel 1AnimalsHumansMiceMitochondriaMitochondrial MembranesProtein MultimerizationVirus Replication4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAntiviral AgentsVDAC1 protein, humanVoltage-Dependent Anion Channel 1apoptosisDIDSin vitro and in vivo antivirusoligomerizationRSVVDAC1

Identifiers

PMID41670372
PMCPMC13011466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.