Evidence map›Paper›PMID 41670371›Full record

ArticleJournal of virology2026

Xingyu Liu, Andrea Bilger, Denis Lee, Prokopios P Argyris, Jiarui Chen, Ella Ward-Shaw, Emilia Barreto Duran, Yu-Hsiu T Lin, Cameron Durfee, Sang H Chun and 5 more

Abstract read
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

15 authors.

Xingyu LiuDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Andrea BilgerMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Denis LeeMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Prokopios P ArgyrisDepartment of Pathology, University of Chicago Medicine, Chicago, Illinois, USA.
Jiarui ChenDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ella Ward-ShawMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Emilia Barreto DuranDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Yu-Hsiu T LinDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Cameron DurfeeDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Sang H ChunDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Mahmoud IbrahimDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Joshua ProehlDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Allen J YorkDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Paul F LambertMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-7983-2755
Reuben S HarrisDepartment of Biochemistry and Structural Biology, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-9034-9112

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 1985 to 2026
$53.1M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Sarat Chandarlapaty, Simon N. Powell · 2020 to 2026
$16.3M
PROJECT 3 – BIOLOGY OF DNA DEAMINASES IN CANCERP01CA234228 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Michael Allen Carpenter · 2019 to 2026
$14.5M
Defining Drivers of HPV-associated CarcinogenesisR35CA210807 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 2017 to 2026
$9.2M
APOBEC3 Proteins in HIV RestrictionR37AI064046 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HARRIS, REUBEN S · 2015 to 2024
$4.2M
APOBEC proteins and uracil in retrovirus restrictionR01AI064046 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HARRIS, REUBEN S · 2005 to 2014
$3.0M
NCI NIH HHS P01 CA022443NCI NIH HHS P01 CA234228NCI NIH HHS P50 CA247749NCI NIH HHS R35 CA210807NIAID NIH HHS R01 AI064046NIAID NIH HHS R37 AI064046
6 · The paper itself

Abstract

The single-stranded DNA deaminase APOBEC3B (A3B) is capable of potently restricting the replication of a range of viruses, including retroviruses (cDNA) and herpesviruses (genomic DNA). However, these and likely other DNA virus families have evolved host species-specific counter-defenses that are equally potent and serve to protect viral DNA from restriction. Although high-risk human papillomavirus (HPV) infection triggers A3B upregulation, potentially as part of an antiviral response, the impact of this restriction factor on papillomavirus replication and pathogenesis has yet to be assessed. To study human A3B antiviral function in the absence of a species-specific counter-defense, here, we ask whether human A3B is capable of restricting

Indexed as

Cytidine DeaminaseMinor Histocompatibility AntigensPapillomaviridaePapillomavirus InfectionsAnimalsDNA, ViralHost-Pathogen InteractionsHuman Papillomavirus VirusesHumansKeratinocytesMiceVirus ReplicationAPOBEC3B protein, humanCytidine DeaminaseDNA, ViralMinor Histocompatibility AntigensAPOBEC3B (A3B)innate antiviral immunitypapillomavirussmall DNA tumor virusvirus-host interactionsvirus restriction mechanisms

Identifiers

PMID41670371
PMCPMC13011340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.