Evidence map›Paper›PMID 41670294›Full record

ArticleAnalytical chemistry2026

Development of an Accurate Double Isotopic Standard LC-MS/MS Method for Hyaluronic Acid Quantification in Biological Matrices.

Simone Manzi, Alessandra Altomare, Giacomo Mosconi, Maria Serena Rossitto, Luciano Messina, Anna Gallo, Marina Carini, Giancarlo Aldini, Giovanna Baron

Abstract read
In one paragraph

Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simone ManziDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.
Alessandra AltomareDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.ORCID 0000-0002-9906-6098
Giacomo MosconiDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.
Maria Serena RossittoFidia Farmaceutici S.p.A., Contrada Pizzuta, Noto, SR 96017, Italy.
Luciano MessinaFidia Farmaceutici S.p.A., Contrada Pizzuta, Noto, SR 96017, Italy.
Anna GalloFidia Farmaceutici S.p.A., Via Ponte della Fabbrica 3/A, Abano Terme, PD 35031, Italy.
Marina CariniDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.
Giancarlo AldiniDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.
Giovanna BaronDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, Milan 20133, Italy.ORCID 0000-0002-9335-6318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronic acid (HA) plays key roles in tissue hydration, repair, and cellular signaling. Its quantification in biological matrices is crucial but challenging due to its endogenous nature and poor mass spectrometric detectability. We developed a robust method based on enzymatic hydrolysis, dual

Indexed as

Hyaluronic AcidLiquid Chromatography-Mass SpectrometrySynovial FluidTandem Mass SpectrometryVitreous BodyAnimalsCarbon IsotopesCattleChromatography, LiquidHumansReference StandardsCarbon IsotopesHyaluronic Acid

Identifiers

PMID41670294
PMCPMC12937047

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.