Evidence map›Paper›PMID 41670228›Full record

Trial reportInternational journal of dermatology2026

Assessing the Dermal Epidermal Junction of Hyperkeratotic Actinic Keratoses via Line-Field Confocal Optical Coherence Tomography.

Simone Michelini, Pietro Scribani Rossi, Giuseppe Gemma, Flavia Persechino, Giordano Vespasiani, Claudio Conforti, Francesco Ricci, Carmen Cantisani, Giovanni Pellacani

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simone MicheliniDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Pietro Scribani RossiDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-5743-8746
Giuseppe GemmaDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Flavia PersechinoDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Giordano VespasianiDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Claudio ConfortiIRCCS Istituto Dermopatico Dell'immacolata (IDI-IRCCS), Dermatological Research Hospital, Rome, Italy.
Francesco RicciIRCCS Istituto Dermopatico Dell'immacolata (IDI-IRCCS), Dermatological Research Hospital, Rome, Italy.ORCID https://orcid.org/0000-0002-8388-9268
Carmen CantisaniDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-2181-951X
Giovanni PellacaniDermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionActinic keratoses (AKs) are ultraviolet (UV)-induced skin lesions that may progress to invasive squamous cell carcinoma. Hyperkeratotic AKs hinder line-field confocal optical coherence tomography (LC-OCT) imaging, limiting assessment of the dermal-epidermal junction (DEJ) and PRO-score, a histopathological index of dermal invasion.

objectiveThe aim of this study was to evaluate whether moisturization improves DEJ visualization and PRO-score evaluation in hyperkeratotic AKs using LC-OCT. MATERIALS AND

methodsFifty-nine hyperkeratotic AKs were randomized to receive either 20-min tap water occlusion or 20% salicylic acid ointment (SAO). LC-OCT scans were taken before and after treatment. DEJ visibility, PRO-score (0-3), and confidence in PRO assignment (cPRO) were rated by blinded evaluators.

resultsDEJ visibility significantly increased posttreatment (from 39.0% to 86.4%, p = 0.015), with no significant difference between water and salicylic acid ointment (SAO). Confidence in PRO-scoring also improved (p < 0.001), and 39.1% of lesions with initial scores were reclassified. G2 AKs had higher DEJ visibility than G3 both before and after treatment.

conclusionMoisturization enhances LC-OCT evaluation of hyperkeratotic AKs, improving DEJ visualization and diagnostic confidence.

Indexed as

DermisEpidermisKeratosis, ActinicSalicylic AcidTomography, Optical CoherenceAgedAged, 80 and overFemaleHumansKeratolytic AgentsMaleOintmentsKeratolytic AgentsOintmentsSalicylic Acidactinic keratosisline‐field confocal optical coherence tomographynoninvasive diagnosticsPRO‐score

Identifiers

PMID41670228
PMCPMC13342758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.