ArticleJournal of the American Heart Association2026
Cardiac Structure Relates to Hemorrhagic Cerebral Small Vessel Disease Phenotype.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Magnetic Resonance Imaging in Cerebral Small Vessel Disease-Related Depression: From Visual Scoring to Artificial Intelligence.CNS neuroscience & therapeutics · 2026Review
- Characterisation of patients with intracerebral haemorrhage with mixed location haemorrhages: clinical and imaging features, CSF neurodegeneration markers and recurrence risk.European stroke journal · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost intracerebral hemorrhages (ICH) are caused by 1 of 2 cerebral small vessel diseases (cSVDs): arteriolosclerosis and cerebral amyloid angiopathy (CAA). Hypertension is a major risk factor for ICH, but its contribution to the hemorrhagic manifestations of these arteriopathies remains uncertain. We investigated associations between a cardiac structural biomarker of systemic hypertension (left ventricular mass [LVM]) and cSVD neuroimaging phenotype in patients with ICH.
methodsWe assessed brain magnetic resonance imaging and echocardiography cross-sectional data from patients with symptomatic hemorrhagic cSVD, including macroscopic ICH, convexity subarachnoid hemorrhage, or cognitive impairment. We compared LVM in patients with possible or probable CAA, mixed pattern cSVD, or arteriolosclerosis. We used linear regression models to investigate associations between LVM, patient characteristics, and SVD.
resultsWe included 216 patients (104 with CAA, 91 with mixed pattern cSVD, and 21 with arteriolosclerosis). Patients with CAA had a significantly lower mean LVM (148.8±44.9 g) compared with those with mixed pattern cSVD or arteriolosclerosis (172.8±59.3 g) (
conclusionsOur findings suggest cardiac structure relates to the neuroimaging phenotype of symptomatic hemorrhagic cSVD, including ICH. This is relevant to the classification, understanding, and prevention of hemorrhagic cSVD.
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