ArticleJournal of the American Heart Association2026
Association of Longitudinal High-Sensitivity Cardiac Troponin T With Clinical Outcomes in Adult Heart-Transplant Recipients.
Liqi Cao, Chulan Ou, Chang Liu, Junqing Yang, Yijin Wu, Xiahui Tian, Xinyi Luo, Shuang Xia, Zhicheng Du, Yiran Jia and 6 more
Abstract read
In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Liqi Cao *Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0000-0003-1861-5006 Chulan Ou *Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0009-0007-9351-2513 Chang LiuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Junqing YangDepartment of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yijin WuDeparment of Heart Transplantation and VAD surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Xiahui TianDepartment of Radiology, Zhujiang Hospital Southern Medical University Guangzhou China.
Xinyi LuoDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Shuang XiaDepartment of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Zhicheng DuDepartment of Medical Statistics, School of Public Health Sun Yat-sen University Guangzhou China.ORCID 0000-0002-1155-8443 Yiran JiaDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0009-0003-7383-3994 Hong ShiDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yanting LiangDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yanxiang LiDepartment of Laboratory Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Hui LiuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0000-0003-0148-0125 Min Wu *Deparment of Heart Transplantation and VAD surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yuelong Yang *Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0000-0002-0611-9366 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundCardiac troponin T is associated with mortality in heart transplantation recipients, but the association between its longitudinal measurements and clinical outcomes has not been evaluated. This study aimed to determine whether 3 parameterizations of serial hs-cTnT (high-sensitivity cardiac troponin T)-instantaneous concentration, temporal trend, and cumulative exposure-are associated with clinical outcomes in this population.
methodsIn a retrospective analysis, 222 heart transplantation recipients (median age 50 years, 86% men) who survived >30 days post transplant were included. Joint models were used to analyze the association between longitudinal hs-cTnT and the primary outcome of all-cause mortality and the secondary outcome of major adverse cardiac events.
resultsOver a median follow-up of 2.3 years, 32 deaths and 41 major adverse cardiac events occurred. Both instantaneous hs-cTnT concentration (hazard ratio [HR], 1.85 [95% CI, 1.48-2.31];
conclusionsLongitudinally measured hs-cTnT is independently associated with mortality and major adverse cardiac events in heart transplant recipients.
Indexed as
Heart TransplantationTroponin TAdultBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeBiomarkersTroponin Tclinical outcomesheart transplantationlongitudinal analysis
Identifiers
PMID41669946
PMCPMC13055809
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390