Evidence map›Paper›PMID 41669875›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine.

Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tan WuDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0009-1074-2757
Xiaoyue XuDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Dan XuDepartment of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hui ZhangDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Nan WangDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Yang YangDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Qian ChenDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-8566-4847
Shunjie ChenDepartment of Nephrology, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Cheng LiDepartment of Anesthesiology and Perioperative medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center For Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.

Funding

Hongkou District Health Commission HKLCFC202405National Natural Science Foundation of China 81770706National Natural Science Foundation of China 82271223School of Medicine, Tongji University sykyqd01902School of Medicine, Tongji University sykyqd09501School of Medicine, Tongji University SY-XKZI-2023-1009School of Medicine, Tongji University SY-XKZT-2023-1001School of Medicine, Tongji University SY-YKYTS-2024-1002Shanghai Academic/Technology Research Leader 23XD1402600Shanghai Fourth People's HospitalShanghai Municipal Committee of Science and Technology for Program of Shanghai Academic/Technology Research Leader 23XD1422900Shanghai Rising-Star Program 24QB2706100Tongji University 2025-0674-YB-01
6 · The paper itself

Abstract

Nanocatalytic therapy is an emerging strategy that leverages in situ catalytic reactions within the tumor microenvironment to convert endogenous substrates into cytotoxic species, achieving spatially confined cancer cell killing with reduced systemic toxicity. However, the lack of durable, DNA-focused cytotoxic mechanisms hampers the translational efficacy of nanocatalytic therapy. Herein, we proposed a cascade nanocatalysis-mediated strategy for endogenous amplification of apoptosis, achieved by an engineered metal organic framework nanomedicine (MOF-Au-L-Arginine, abbreviated as MAL). The MOF serves both as a nanocatalyst and as a carrier for L-Arginine (L-Arg), while embedded Au nanoparticles enhance nanocatalyst reactivity. Subsequently, MOF catalyzes the generation of hydroxyl radicals (•OH) and superoxide anions (O

Indexed as

ApoptosisNanomedicineTumor Suppressor Protein p53AnimalsArginineCatalysisCell Line, TumorHumansMetal NanoparticlesMiceArginineTumor Suppressor Protein p53colorectal cancerDNAMOFnanocatalysisp53 proteinperoxynitrite

Identifiers

PMID41669875
PMCPMC13045313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.