Evidence map›Paper›PMID 41669700›Full record

ArticleClinical case reports2026

Drug-Resistant Sinus Tachycardia as a Dose-Dependent Side Effect of Spironolactone: A Case Report and Review of the Literature.

Zahra Abdi, Maryam Chenaghlou, Aysa Rezabakhsh, Laya Hooshmand Gharabagh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zahra AbdiCardiovascular Research Center Tabriz University of Medical Sciences Tabriz Iran.
Maryam ChenaghlouCardiovascular Research Center Tabriz University of Medical Sciences Tabriz Iran.ORCID https://orcid.org/0000-0002-2376-0913
Aysa RezabakhshPatient Safety Research Center, Clinical Research Institute Urmia University of Medical Sciences Urmia Iran.ORCID https://orcid.org/0000-0003-3942-7848
Laya Hooshmand GharabaghDepartment of Internal Medicine, School of Medicine Imam Khomeini Hospital, Urmia University of Medical Sciences Urmia Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spironolactone is widely used for polycystic ovarian syndrome due to its anti-androgenic properties. However, rare cardiovascular side effects may occur even in normotensive patients. We report a case of severe palpitations and drug-resistant sinus tachycardia following high-dose therapy, emphasizing the need for cautious titration and cardiac monitoring.

Indexed as

adverse eventmineralocorticoid receptor antagonistpolycystic ovarian syndromereflex tachycardiaspironolactone

Identifiers

PMID41669700
PMCPMC12883336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.