ArticleSmall science2026
Detection of Cancer-Associated Mutations Using Primer Exchange Reaction-Based Signal Amplification and Lateral Flow Assays.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The ability to sensitively and specifically detect cancer-associated nucleic acids carrying single-nucleotide mutations is critical for early cancer detection, patient stratification, and personalized treatment, particularly through non-invasive liquid biopsy approaches. Detecting low-abundance nucleic acid fragments-particularly those with single-nucleotide variations-remains a significant challenge for point-of-care (POC) diagnostics. Here, we report a programmable DNA-based self-assembly strategy that leverages primer exchange reaction (PER) for isothermal signal amplification and enables colorimetric detection of cancer-specific DNA and RNA fragments on gold nanoparticle-based lateral flow assays (LFAs). This method uses PER-generated DNA concatemers functionalized with multiple FITC-labeled imager strands to enhance the visual signal on conventional LFA strips. We demonstrate that this approach enables detection of a synthetic
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