ReviewCureus2026
Clinico-Radiological Presentation and Management of Gallbladder Paraganglioma: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder paraganglioma (GPG) is a rare neuroendocrine tumour discovered incidentally on final histopathological examination. The objective was to evaluate the clinical findings and management strategies using relevant literature for reported cases of gallbladder paraganglioma. A Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided literature search was conducted using data from PubMed, Scopus, and Google Scholar to identify the studies with histopathologically confirmed cases of GPG published between January 2000 and December 2024. Study quality was assessed using the Joanna Briggs Institute checklist, and data analysis was done using descriptive statistics and tabulations. A total of 13 case reports were selected, satisfying the inclusion and exclusion criteria. Among 13 reported cases, 10 (76.3%) were females. The mean age of the patients was 53.8 ± 12.59 years. Right hypochondrial pain was the most common presentation in seven (53.9%) cases, while three (23.1%) cases were asymptomatic. Ultrasound was the initial imaging modality in seven (53.9%) patients, followed by computed tomography scans in six (46.2%). Histopathology showed a nested pattern of chief and sustentacular cells in five (38.5%) cases. On immunohistochemistry, 11 (84.6%) cases were positive for synaptophysin A and nine (69.2%) were positive for chromogranin A. Laparoscopic cholecystectomy was the most common procedure performed in 10 (76.3%) cases. The average duration of follow-up was 66.5 ± 82.10 weeks, which was mentioned for only five patients. GPG should be considered in the differential diagnosis of gallbladder and biliary disorders presenting with features of acute cholecystitis and non-functional tumours. Patients often present with non-specific symptoms aligning with mass effects and cholecystitis. When a growth is suspected, it should be thoroughly evaluated before surgery to rule out other types of invasive gallbladder tumours. If investigations confirm a non-metastatic lesion, proceeding with a simple cholecystectomy is appropriate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.