ArticleCureus2026
Assessing Cardiovascular Dysfunction Using Cardiac Strain After Diphenhydramine Overdose.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diphenhydramine overdose is a dangerous condition that typically leads to symptoms of antimuscarinic toxicity and dysrhythmias. Left ventricular (LV) systolic dysfunction is a manifestation of diphenhydramine toxicity that commonly presents with electrocardiogram (ECG) findings of QRS prolongation. This article presents the case of a patient who was brought to the emergency department (ED) after a diphenhydramine overdose and was showing signs of antimuscarinic toxicity, with an ECG showing no signs of QRS interval prolongation. Point-of-care echocardiography and speckle tracking were performed, which showed a preserved ejection fraction (EF) and reduced global longitudinal strain (GLS), suggestive of subtle LV systolic dysfunction. The patient was treated with intravenous fluids and rivastigmine; his symptoms improved appropriately, and he was discharged the following day. This case report highlights the sensitivity of GLS in unveiling LV systolic dysfunction in patients with preserved EF and a normal ECG, showing its potential utility in patients presenting to the ED with substance overdoses.
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