ArticleQuantitative imaging in medicine and surgery2026
Clinical application of PRIMARY score in diagnosing clinically significant prostate cancer: a comparative study using
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The PRIMARY score was developed to standardize the evaluation of intraprostatic prostate-specific membrane antigen (PSMA) activity on gallium-68 ( Methods: This retrospective study included 192 patients who underwent PSMA PET/CT and systematic biopsy. PRIMARY scores were categorized as PET-positive (score 3-5) or PET-negative (score 1-2). PSMA uptake patterns were categorized as no pattern, diffuse transition (TZ)/central zone (CZ) (non-focal), focal TZ, or focal peripheral zone (PZ). Diagnostic metrics [sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV)] were calculated against histopathology. DeLong test was used to compare the areas under the receiver operating characteristic (ROC) curves (AUCs) of the PRIMARY score and maximum standardized uptake value (SUVmax). Univariate logistic regression assessed associations between SUVmax and csPCa by pattern, reporting odds ratios (ORs) with 95% confidence intervals (CIs). Results: The csPCa detection rates were 35.6% (21/59) for Conclusions: The PRIMARY score improves the diagnostic accuracy for csPCa in
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