ArticleQuantitative imaging in medicine and surgery2026
Comprehensive cardiac magnetic resonance imaging in patients with idiopathic premature ventricular contractions: role of feature-tracking strain and T1/T2 mapping in detecting subclinical myocardial dysfunction.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although standard cardiac magnetic resonance (CMR) findings are typically normal in patients with idiopathic premature ventricular contractions (PVCs), it remains unclear whether a comprehensive protocol incorporating left ventricular (LV) strain and tissue characterization can detect subclinical myocardial abnormalities. This study aimed to determine if advanced CMR parameters can reveal a burden-dependent myocardial phenotype in patients with idiopathic PVCs. Methods: In this retrospective study, 72 patients with idiopathic PVCs and 25 controls underwent comprehensive 3T CMR with feature-tracking (FT) strain analysis and native T1/T2 mapping. Patients were stratified by 24-hour PVC burden into three groups: <500 PVC/24 h (n=24), 500-10,000 PVC/24 h (n=23), and >10,000 PVC/24 h (n=25). Results: Compared to controls, patients with >10,000 PVC/24 h (high burden) exhibited significantly impaired myocardial strain after multiple-comparison correction, including reductions in two-dimensional (2D) global radial (27.4%±7.0% Conclusions: As a hypothesis-generating study, our work, based on comprehensive CMR assessment, identified a novel, burden-dependent myocardial phenotype in patients with idiopathic PVC. The discovery of this phenotype, characterized by distinct patterns of systolic dysfunction and interstitial alterations, should be examined in terms of its clinical and prognostic significance in subsequent longitudinal studies.
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