ArticleQuantitative imaging in medicine and surgery2026
Diagnostic utility of two-dimensional speckle tracking imaging in detecting subclinical left ventricular systolic dysfunction in patients with alcohol-related disorders.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alcohol-related disorders affect 4.5-7.8% of Chinese adults and are known to precipitate alcoholic cardiomyopathy; nevertheless, conventional left ventricular ejection fraction (LVEF) often remains within the normal range in early disease, so a more sensitive marker of incipient systolic injury is needed. This study aims to quantify the diagnostic performance of two-dimensional speckle tracking imaging (2D-STI) for detecting sub-clinical left ventricular systolic dysfunction in patients with alcohol-related disorders. Methods: Consecutive 50 in-patients (100% male, age 47.21±4.57 years) fulfilling diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) criteria for alcohol-related disorder and 50 age- and sex-matched healthy controls were prospectively enrolled. All subjects underwent the same Philips EPIQ-7C scan (frame-rate ≥60 Hz). Global longitudinal (GLS), circumferential (GCS) and radial strain (GRS) together with their systolic strain rates were measured off-line (using advanced cardiac mechanics quantification analysis Software, aCMQ software). Conventional Simpson-derived left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and ejection fraction were also obtained. Between-group comparisons used unpaired Results: Compared with control group, patients with alcohol-related disorders showed higher (less negative) GLS (-13.5%±2.1% Conclusions: In males with alcohol-related disorders, 2D-STI consistently reveals multidirectional strain deficits that correlate tightly with conventional left ventricular volumes and ejection fraction, supporting its use for early detection of sub-clinical systolic dysfunction.
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