ArticleTherapeutic advances in medical oncology2026
Immunotherapy for locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of randomized clinical trials.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Integrated bioinformatics and experimental validation identifies CLIC6 as a novel tumor suppressor regulating NF-κB signaling and immune microenvironment in nasopharyngeal carcinoma.Translational oncology · 2026Article
- Comment on "Immunotherapy for locoregionally advanced nasopharyngeal carcinoma: A meta-analysis of randomized clinical trials".Therapeutic advances in medical oncology · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Locoregionally advanced nasopharyngeal carcinoma (LANPC) is the predominant stage at diagnosis and is commonly treated with cisplatin-based chemoradiotherapy (CRT). Although this approach achieves excellent locoregional control, distant metastasis remains the leading cause of treatment failure. Immunotherapy with programmed cell death protein 1 (PD-1) inhibitors, supported by the immunogenicity of Epstein-Barr virus-associated disease, has emerged as a promising strategy. Objectives: To synthesize evidence from phase III trials on the efficacy and safety of PD-1 blockade combined with definitive chemoradiotherapy in LANPC. Design: Systematic review and meta-analysis of randomized controlled trials. Data sources and methods: We systematically searched for phase III randomized controlled trials evaluating PD-1 blockade plus chemoradiotherapy versus chemoradiotherapy (with or without placebo) in previously untreated LANPC. Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted for event-/failure-free survival (EFS/FFS), overall survival (OS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Pooled effects were estimated with random-effects models, with heterogeneity assessed using Results: Three trials including 1237 patients were identified. PD-1 blockade significantly improved EFS/FFS (HR 0.66, 95% CI: 0.49-0.89; Conclusion: This first meta-analysis of phase III evidence demonstrates that PD-1 blockade combined with cisplatin-based chemoradiotherapy improves disease control in LANPC without added toxicity. Longer follow-up from ongoing studies is needed to establish the OS benefit and optimize treatment strategies. Trial registration: PROSPERO CRD-420251147756.
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