The AENEAS Project: Intraoperative Anatomical Guidance Through Real-Time Landmark Detection Using Machine Vision.

Objective: To investigate the performance of a deep learning machine vision-based model in identifying anatomical landmarks in a complex microsurgical setting, such as the pterional trans-Sylvian approach. Patients and Methods: We developed a deep learning object detection model (YOLOv7x) trained on 5307 labeled frames from 78 surgical videos of 76 patients undergoing pterional trans-Sylvian approach from January 1, 2020 to June 31, 2024. Surgical steps were standardized, and key anatomical targets-frontal/temporal dura, inferior frontal/superior temporal gyri, optic and olfactory nerves, and internal carotid artery-were annotated by specifically trained neurosurgical residents and verified by the operating surgeon. Bounding boxes derived from segmentation masks served as training inputs. Performance was evaluated using 5-fold cross-validation. Results: The model achieved promising detection performance for deep structures, particularly the optic nerve (average precision at an intersection over union threshold of 0.50 [AP Conclusion: Applying machine vision techniques for anatomical detection in a complex neurosurgical setting is feasible. Although challenges remain in detecting less distinctive structures, the high accuracy achieved for deep anatomical landmarks validates this approach. This study marks an essential step toward the development of machine vision-powered anatomical recognition tools, with the prospective goal of improving intraoperative orientation and reducing variability among surgeons.