Evidence map›Paper›PMID 41669365›Full record

ArticleMindfulness2022

A Pilot Randomized Controlled Trial Investigating MBSR for Parkinson's Disease Patients and Their Caregiving Partners: Effects on Distress, Social support, Cortisol, and Inflammation.

Chelsea J Siwik, Kala Phillips, Irene Litvan, Paul Salmon, Allison Rodgers, Megan Jablonski, Sandra E Sephton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mindfulness, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chelsea J SiwikDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.
Kala PhillipsDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.
Irene LitvanParkinson and Other Movement Disorder Center, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Paul SalmonDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.
Allison RodgersDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.
Megan JablonskiDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.
Sandra E SephtonDepartment of Psychological and Brain Sciences, University of Louisville, 2301 S 3rd St., Louisville, KY 40292, USA.

Funding

Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
NCCIH NIH HHS T32 AT003997
6 · The paper itself

Abstract

Objectives: To examine the preliminary effects of the mindfulness-based stress reduction (MBSR) program in the management of biopsychosocial stress-related changes associated with Parkinson's disease (PD) among patient/caregiving-partner dyads. Methods: PD patient/caregiving-partner dyads ( Results: No participants were lost to follow-up. Given the pilot nature of the current investigation, findings should be interpreted as exploratory opposed to confirmatory. Following MBSR, PD patients reported an increase in disease-specific distress and intrusive thoughts and demonstrated a decrease in mean bedtime cortisol and IL-1beta from baseline to follow-up compared to TAU. Caregiving partners who received MBSR reported an increase in perceived social support and demonstrated improved rhythmicity of diurnal cortisol slopes from baseline to follow-up compared to TAU. Conclusions: Both patients and caregiving partners who received MBSR demonstrated improvements in biomarkers of circadian function, and patients evidenced a decrease in a biomarker of systemic inflammation, pointing to an important area of further investigation. Given that patients reported an increase in disease-specific distress and intrusive thoughts, the salutary effects of MBSR may be experienced physiologically prior to, or in lieu of, psychological effects, although this should be explored further, especially given the improvement in perceived social support reported by caregiving partners.

Indexed as

CaregiverCortisolInflammationMBSRParkinson’s diseasePatient-partner dyads

Identifiers

PMID41669365
PMCPMC12885365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.