ArticleAdvanced biomedical research2025
Elective HFOV vs CMV as Early Intervention: A Clinical Trial in Neonates with Acute Respiratory Distress Syndrome.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: While Synchronized Intermittent Mandatory Ventilation with Volume Guarantee (SIMV + VG) is commonly used for mechanical ventilation in preterm infants with respiratory failure, High-Frequency Oscillatory Ventilation (HFOV) is often reserved for cases unresponsive to conventional modes. Given the inconclusive findings on the early HFOV, this trial compares SIMV + VG and HFOV as initial ventilation strategies in preterm infants with respiratory distress syndrome (RDS). Materials and Methods: This randomized controlled trial included 86 neonates (25-35 weeks' gestation) with RDS, enrolled from 2020 to 2023 at two tertiary referral hospitals affiliated with Isfahan University of Medical Sciences, Iran. Using stratified block randomization by birth weight, neonates were assigned to either the HFOV or SIMV + VG group ( Results: The HFOV group showed significantly shorter intubation duration (3.80 vs. 8.62 days, Conclusion: Early HFOV application in preterm neonates with RDS significantly reduces intubation duration, NIPPV duration, and BPD incidence. These findings suggest potential benefits of HFOV in improving neonatal outcomes. Further multi-center studies with long-term follow-up are warranted to validate these results and explore broader clinical implications.
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