Evidence map›Paper›PMID 41669197›Full record

ArticleFrontiers in radiology2025

Minimizing contrast agent dosage in CT angiography using a saline chaser with a low trigger threshold.

Linghan Li, Xiaojian Zhu, Xunhua Wu

Abstract read
In one paragraph

Article in Frontiers in radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linghan LiDepartment of Radiology, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, China.
Xiaojian ZhuDepartment of Radiology, Chaling People's Hospital, Zhuzhou, Hunan, China.
Xunhua WuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Computed tomography angiography (CTA), utilizing iodinated contrast agents, is a first-line diagnostic tool for cardiovascular diseases (CVD). However, the administration of contrast agents introduces potential risks to patients. Objective: This study aims to design a novel protocol for CTA that integrates a saline chaser strategy and low-threshold triggering and evaluate, and demonstrate its feasibility and practicality minimizing the required contrast agent for imaging. Methods: A novel protocol for CTA incorporating a saline chaser strategy and low-threshold triggering was developed. Random assignment of eighty patients undergoing CTA examinations divided them into conventional and novel protocol groups. The assessment encompassed iodine intake, radiation dose, image quality, and superior vena cava artefacts in both cohorts. Results: The novel protocol group exhibited a noteworthy 20% reduction in iodine intake compared to the conventional group ( Conclusion: The combination of saline chaser strategy with low-threshold triggering in CTA imaging proves a viable approach, significantly curtailing the utilization of iodinated contrast agents, and superior vena cava artefacts.

Indexed as

computed tomography angiographycontrast-induced nephropathyimage qualityiodine contrast agentsaline chaser

Identifiers

PMID41669197
PMCPMC12883799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.