ArticleAlzheimer's & dementia (New York, N. Y.)
Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Not just how much, but how it's done: movement activity bout distributions and everyday cognition in older adults with elevated dementia risk.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Response to "Reanalyzing the impact of cognitive training over 20 years in the ACTIVE study: Losing the forest in the trees".Alzheimer's & dementia (New York, N. Y.)Article
- Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
introductionThe very long-term effect of cognitive training on the risk of Alzheimer's disease and related dementias (ADRD) is unknown.
methodsThis study links data from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study (a four-arm randomized controlled trial of cognitive training in a large, diverse sample) to Medicare claims (1999 to 2019). Inclusion in the analyses required being enrolled in traditional Medicare at baseline (
resultsParticipants randomized to the speed-training arm who completed one or more booster sessions had a significantly lower risk of diagnosed ADRD (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.59, 0.95), while speed-trained participants with no booster training did not have a lower risk of diagnosed ADRD (HR: 1.01, 95% CI: 0.81, 1.27). There was no main effect of memory or reasoning training on risk of ADRD.
conclusionsCognitive training involving speed of cognitive processing has the potential to delay the diagnosis of ADRD. Highlights: The ACTIVE study (a four-arm randomized controlled trial of cognitive training in a large, representative sample) reports that the speed intervention arm of the study showed a reduced likelihood of being diagnosed with ADRD over a 20-year follow-up period.No prior cognitive training intervention has been shown to reduce risk of ADRD over a 20-year period.Cognitive training involving speeded, dual attention, adaptive tasks has the potential to delay the diagnosis of ADRD.
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