ReviewImmunity & inflammation2025
Leveraging T cells for cancer immunotherapy.
Review in Immunity & inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Neural-immune tango in cancer: PNS and CNS as emerging conductors of cancer immunosurveillance.MedScience · 2026Article
- Mechanism-Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Peripheral T-Cell Receptor β Repertoire Dynamics Correlate with Response to Anti-PD-L1 Therapy in Non-Small Cell Lung Cancer.Cancers · 2026Article
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8Nature communications · 2026Article
- Tumor microenvironment dynamics in gastric cancer pathogenesis and therapeutic resistance.Molecular cancer · 2026Review
- WDR82 suppresses breast cancer progression by inhibiting ERK-driven chemokine expression and neutrophil infiltration.International journal of biological sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells play an essential role in tumour prevention and control, however, avoidance or disruption of anti-tumour T cell responses frequently leads to tumour progression and malignant disease. Immunotherapy aims to address this breakdown in T cell-mediated anti-tumour immunity and restore T cell function to promote the elimination of cancerous cells. Although immunotherapy has led to drastic improvements in patient prognoses across a range of clinical setting, most patients still fail to exhibit a durable therapeutic response. In this review we discuss the role of T cells in controlling tumour progression, how T cell immunity is avoided or disrupted in the context of malignant disease, and the mechanisms by which soluble, cellular, or vaccine-based immunotherapies aim to restore anti-tumour T cell responses. This review does not aim to provide a comprehensive summary of approved immunotherapies, nor does it focus on the logistical challenges faced during the development or clinical application of immunotherapy. Instead, this review aims to highlight the mechanisms by which different therapeutic approaches address, or fail to address, specific aspects of the breakdown in T cell-mediated anti-tumour immunity. This review will also discuss exciting pre- and early-stage clinical developments that may improve the therapeutic efficacy and applicability of these treatments by more comprehensively addressing the challenges faced by T cells to improve patient prognoses. Graphical Abstract:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.