ReviewMedicine international
Radiation-induced alterations in the cancer microenvironment (Review).
Review in Medicine international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation therapy is routinely used for the treatment of cancer; however, the development of radiation resistance in some tumor cells can lead to poor efficacy. Cancer cells can alter their metabolic status following exposure to radiation to reduce radiation-induced cytotoxicity, ultimately enabling them to survive radiation injury and adapt to the changed environment. It has been indicated that these metabolic changes in cancer cells affect the cancer microenvironment, and certain metabolite changes within the microenvironment may, in turn, promote cancer cell proliferation. Therefore, combining radiotherapy with targeted metabolic treatments may enhance the effectiveness of cancer therapy. The present review discusses the metabolic reprogramming of cancer cells following radiotherapy, and the resulting microenvironmental metabolic characteristics. Furthermore, the present review introduces the novel findings on innate nano-confinements, which may influence the cancer microenvironment by regulating energy metabolism and signaling pathways through new mechanisms.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.