ArticleEuropean journal of case reports in internal medicine2026
Isolated Pulmonary Light Chain Deposition Disease.
Article in European journal of case reports in internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pulmonary involvement is a significant aspect of many autoimmune diseases. Different pulmonary manifestations of autoimmune diseases encompass a variety of conditions that impact the lungs, including interstitial lung disease, cystic lung disease, pulmonary hypertension, and pleural involvement. One rare manifestation is light-chain deposition disease. Our case report aims to highlight the condition's rarity and presentation variability. Case presentation: A 55-year-old Caucasian female with a history of Sjögren's syndrome, papillary thyroid carcinoma status post thyroidectomy, and chronic leukopenia underwent a computed tomography (CT) of the chest for routine oncological surveillance. Imaging revealed an 8 mm left upper lobe nodule with bilateral bullous lung changes. A positron emission tomography/CT showed mildly Conclusion: Pulmonary light chain deposition disease is an infrequent condition requiring a high index of suspicion for diagnosis. Imaging findings can help identify it, but biopsy remains the definitive diagnostic tool. Due to the lack of established management guidelines, treatment is personalized based on disease extent and organ involvement. Further research is needed to understand better this rare entity's prognosis and optimal treatment approaches. LEARNING POINTS: Pulmonary light-chain deposition disease is a rare and under-recognized manifestation.Clinicians must have a high index of clinical suspicion while evaluating cystic lung disease, particularly in the background of an autoimmune disease.This case reinforces the importance of considering light chain deposition disease as a differential in evaluation of unexplained lung nodules or cysts.
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