ArticleBiomedical reports2026
Assessing preoperative biopsy accuracy in endometrial carcinoma: A preliminary low- and middle-income country-based report.
Article in Biomedical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preoperative histopathology is key for guiding the extent of surgical management in endometrial carcinoma (EC). However, the concordance between preoperative endometrial curettage and final histopathology is unclear in low- and middle-income countries. The present pilot study aimed to evaluate the accuracy of preoperative curettage in a Bangladeshi referral center and compare the results with data from middle- and high-income settings. The present cross-sectional study was performed at a single tertiary center (Department of Gynecological Oncology, National Institute of Cancer Research and Hospital; Dhaka, Bangladesh) to assess agreement between preoperative endometrial curettage and final surgical histopathology for histological subtype and International Federation of Gynecology and Obstetrics (FIGO) grade. Diagnostic performance metrics (sensitivity, specificity, positive and negative predictive values) and Cohen's κ were calculated. A total of 48 patients with EC were included. The mean age was 53.77±13.03 years. For endometrioid vs. non-endometrioid classification, sensitivity was 93.9 (31/33; 95% CI 79.8-99.3) and specificity 20.0% (3/15; 95% CI 4.3-48.1). Accuracy for tumor grading was 77.1% for FIGO grade 1 (95% CI 62.7-88.0), 79.2% for grade 2 (95% CI 65.0-89.5) and 93.8% for grade 3 (95% CI 82.8-98.7), yielding an overall κ-value of 0.45 (95% CI 0.21-0.70); 66.7% of presumed grade 1 tumors were ultimately upgraded, underscoring the risk of undertreatment if relying exclusively on preoperative biopsy. Preoperative curettage demonstrated moderate accuracy in predicting final pathology. Given the very small non-endometrioid numbers and only moderate overall agreement, preoperative curettage findings should be interpreted alongside clinical judgment; adjunct modalities (imaging, immunohistochemical markers) may be helpful where available but were not evaluated in the present study. These preliminary single-center estimates from a low-middle income country should be interpreted with caution given the small sample and limited generalizability; larger multicenter studies are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.