ArticleFrontiers in allergy2026
Esophageal tissue immunoglobulin G4 in eosinophilic esophagitis and its correlation with serum-specific IgG4 to six foods.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Dietary Approaches in Eosinophilic Esophagitis.Nutrients · 2026Review
- The Potential Link Between Eosinophilic Esophagitis and Food Allergy: Inflammatory Pathogenesis and Management.Journal of inflammation research · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & aims: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder in which IgG4 involvement is unclear. We aimed to evaluate immunoglobulin G4 (IgG4) in eosinophilic esophagitis (EoE) and investigate the correlation among IgG4-positive plasma cells in esophageal tissue, total serum immunoglobulin E (IgE), specific IgE, and specific IgG4 (sIgG4) levels to six foods (milk, egg, wheat, soy, peanut, and seafood). Methods: A retrospective observational study with prospective patient inclusion was conducted from 2017 to 2024 in a real-world setting. Clinical, endoscopic, therapeutic, and outcome characteristics of the patients were collected. Positive staining was defined as >10 IgG4-positive plasma cells per HPF. Peripheral blood analyses included measurements of total IgE, specific IgE, and sIgG4. Results: Seventy-eight patients were included. Patients with positive histological staining exhibited a significantly higher proportion of endoscopic edema (16.1% vs. 2.1%) ( Conclusion: Serum sIgG4 levels to casein and egg were associated with infiltration of IgG4-positive plasma cells in esophageal tissue and a worse disease prognosis.
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