Observational studyJournal of cardiovascular electrophysiology2026
Prognostic Impact of New-Onset Atrial Fibrillation After Cardiac Arrest: Observations From a Federated Research Network.
Observational study in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
backgroundData on adverse events in patients developing atrial fibrillation (AF) after cardiac arrest (CA) are limited.
methodsRetrospective analysis using the TriNetX network. Adults (≥ 18 years) with CA (ICD-10-CM I46) from 2014 to 2024 were divided into two cohorts: those with new-onset AF (I48) within 2 days after CA and those without. Primary outcome was the 1-year risk of a composite of all-cause death, stroke, acute myocardial infarction (AMI), and recurrent CA. Secondary outcomes were the individual components. Cox regression provided hazard ratios (HRs) and 95% confidence intervals (CIs) before and after 1:1 propensity score matching (PSM). Sensitivity analyses stratified follow-up into early (3-33 days) and late (34-367 days) phases; subgroups included age, sex, hypertension, diabetes, heart failure, and shockable rhythms.
resultsWe identified 1221 patients with post-CA AF (mean age 65 ± 14.9 years; 33.8% female) and 149 222 without AF (57.9 ± 17.6 years; 39.3% female). Before PSM, AF patients were older and had greater cardiovascular burden. After PSM post-CA AF was associated with higher risk of the composite outcome (HR 1.25, 95% CI 1.13-1.38), AMI (HR 1.59, 95% CI 1.30-1.95), recurrent CA (HR 1.48, 95% CI 1.30-1.70), and a non-significant trend toward increased stroke risk, which was greater during the early phase post-CA. Female patients showed stronger association between post-CA AF and stroke (p for interaction = 0.04).
conclusionPost-CA AF is associated with an increased risk of adverse events, including AMI and recurrent CA. Stroke risk was higher during the early post-resuscitation phase and among female patients.
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