ArticleJournal of the American Chemical Society2026
Automated Assembly of Polyglucuronic Acids for Structural Explorations.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- 3-Deoxy-3-Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyuronic acids are important biopolymers in marine organisms, where they contribute to extracellular matrix modulation, cell signaling, and carbon cycling. However, the intrinsic structural heterogeneity of polyuronic acids has hindered efforts to establish clear structure-function relationships. Here, we report an automated glycan assembly (AGA) approach that enables the precise synthesis of β-(1-4)-linked d-glucuronic acid (GlcA) oligomers with defined chain lengths and glycosidic linkage stereochemistry. Molecular dynamics simulations revealed a characteristic 2-fold helical conformation, with rigidity in short oligomers and enhanced flexibility emerging in longer sequences. The calcium binding behavior of these oligomers was explored by NMR titrations, revealing diffuse electrostatic binding rather than localized chelation. Polyglucuronic acid (PGA) oligomers are a well-defined molecular model for dissecting ion-mediated interactions and provide a framework for designing uronic acid-based glycomaterials with tunable properties.
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Registered trials
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