Traces of Elements in the Electrochemical Reductive Amination of Acetone: Uncovering Bi as Substitute for Pb.

Justus Kümper, Yani Guan, Simran Kumari, Sonja D Mürtz, Philippe Sautet, Regina Palkovits

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Justus KümperChair of Heterogeneous Catalysis and Technical Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0004-8306-6853

Yani GuanDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0009-0005-2729-0217

Simran KumariDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6963-6566

Sonja D MürtzChair of Heterogeneous Catalysis and Technical Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0003-2647-8881

Philippe SautetDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8444-3348

Regina PalkovitsChair of Heterogeneous Catalysis and Technical Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-4970-2957

Funding

Agency for Renewable Resources 2220NR101XCluster of Excellence "Fuel Science Center" 390919832Cluster of Excellence "The Integrated Fuel & Chemical Science Center" 390919832National Science Foundation 2140374

6 · The paper itself

Abstract

Amines are broadly utilized as solvents, pharmaceuticals, herbicides, or materials. A benign synthesis route to produce amines from carbonylic substrates is the electrochemical reductive amination, whereby electrons combined with a green proton source like water serve as formal reducing agent. Surprisingly, investigating various p-block elements as mediator for the electrochemical conversion of acetone in presence of methylamine revealed that only elements of the sixth period show an activity. Building up on these findings and the general low toxicity of Bi compared to Tl or Pb, the electrochemical hydrogenation of N-methylpropan-2-imine was optimized by studying the effect of Bi concentration, reaction temperature, and cathode material. Thus, this work highlights Bi as innovative mediator for the electrochemical reductive amination, whereby in presence of a few ppm-amounts of Bi at ambient temperatures high amine yields are achievable.

Indexed as

bismuthelectrochemistryimpuritiesleadreductive amination

Identifiers

PMID41668412

DOI10.1002/anie.202521065

PMCPMC13007573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.