ArticleBiophysical journal2026
A kinetic proofreading argument to understand the role of H3K9 trimethylation in phase-separated chromatin states.
Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Histone trimethylation on the tail residue H3K9 of nucleosomes is a hallmark of constitutive heterochromatin. The mechanism of how this mark is maintained over cell division cycles remains a topic of ongoing debate. The recent formulation of the polymer-assisted condensation scenario, through which a stable droplet condensate can form as a reaction container for methylation reactions, has offered a novel approach to answer this long-standing question. In this letter, we develop a kinetic proofreading argument for histone tail methylation that builds on the polymer-assisted condensation model and yields support to the idea that liquid-liquid phase separation underlies the reconstitution of heterochromatin over cell division cycles.
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