ArticleAllergy2026
Elevated CO
Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundClimate change increases exposure to pollen, but the effects of climate-related factors on the potency of pollen to trigger early events in the epithelium are unknown, despite their significant impact on respiratory health.
objectiveWe aimed to investigate whether climate change affects the capacity of grass pollen to mediate cell functions in human nasal epithelium.
methodsToxicological and immunological responses, and the transcriptomes were analyzed after exposing reconstituted human nasal epithelial tissues to pollen collected from grasses (timothy and meadow foxtail) grown under different climate change conditions (increasing temperature and CO
resultsPollen of both grass species grown under current climate conditions altered the expression of genes encoding for cytokines and chemokines, and similar patterns were observed at the protein level. Moreover, pollen exposure reduced epithelial barrier integrity and was associated with increased expression of genes related to tight junctions and tissue repair. Climate change-modified meadow foxtail pollen decreased the expression of genes related to vesicle-mediated transport and transcriptional and translational processes, whereas pollen of timothy grass inhibited the expression of genes related to cilium assembly and organization.
conclusionsFuture grass pollen potentially disrupts cilia function and vesicle-mediated (cytokine) signaling in human nasal epithelium more than pollen representing current climate. That may hinder appropriate immune reaction activation and foreign substance removal from the airways. Disrupted regulation of gene expression in turn potentially results in adverse system-level outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.