Evidence map›Paper›PMID 41668275›Full record

ArticleCancer science2026

KRAB Zinc-Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression.

Xiaofen Huang, Yingchuan Yang, Yuan Ma, Wei Hao, Jingzhuo Jin, Yue Ding, Yiming Zhang, Xiuyuan Zhang, Xinli Li, Qin Song and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiaofen HuangSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.
Yingchuan YangCollege of Life Sciences, Shandong Normal University, Jinan, China.
Yuan MaSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.
Wei HaoSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.
Jingzhuo JinState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing, China.
Yue DingSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.
Yiming ZhangState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing, China.
Xiuyuan ZhangState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing, China.
Xinli LiState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing, China.
Qin SongCollege of Life Sciences, Hebei University, Baoding, China.
Jiaqi LiuCollege of Life Sciences, Hebei University, Baoding, China.
Bingxin LiuCollege of Life Sciences, Hebei University, Baoding, China.
Yuanjun ZhaiCollege of Life Sciences, Hebei University, Baoding, China.
Chunling ZhaoSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.
Jin WuDepartment of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Chunyan TianSchool of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China.ORCID https://orcid.org/0000-0003-1589-293X

Funding

National Key Research and Development Program of China 2024YFA1307704National Natural Science Foundation Projects of China 81572578National Natural Science Foundation Projects of China 82573043the National Natural Science Foundation of Shandong ZR2021MH174
6 · The paper itself

Abstract

The tumor suppressor p53 is frequently dysregulated in cancer, whereas the mechanisms underlying its functional impairment remain unclear. Our previously identified KRAB domain-containing zinc finger proteins (KZFPs) as key p53 regulators in tumorigenesis and progression, specific members and their cancer-relevant mechanistic roles require further characterization. Here, we identified ZNF205, an SQ/TQ motif-bearing KZFP, as a critical oncogenic regulator in HCC. The pan-cancer analysis related to revealed that ZNF205 is an unfavorable prognostic factor for p53 wild-type patients with hepatocellular carcinoma (HCC). ZNF205 interacts with p53 and significantly inhibits its transcriptional activity by impeding the binding of p53 to target genes. Overexpression and knockdown of ZNF205 increase and decrease the malignant phenotype of HCC cells in a p53-dependent manner both in vitro and in vivo, respectively. Our study unveils ZNF205 as a novel p53 regulator and establishes its pro-tumorigenic function in HCC. These results reveal a novel p53 dysregulation mechanism in HCC and expand known KZFP-mediated p53 inactivation pathways, nominating ZNF205 as a therapeutic target to restore p53 function in HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsRepressor ProteinsTumor Suppressor Protein p53AnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMicePrognosisSignal TransductionZinc FingersRepressor ProteinsTP53 protein, humanTumor Suppressor Protein p53hepatocellular carcinomaKRABp53zinc finger proteinZNF205

Identifiers

PMID41668275
PMCPMC13045463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.